Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy
Drug resistance is one of the major causes of cancer-related deaths.Here, the authors using single cell NosiLife Socks RNA-seq of oral squamous cell carcinoma patient samples pre- and post-cisplatin treatment show that phenotypically homogenous cell populations display cell state plasticity, Wall Decor with poised chromatin marks at mesenchymal gen